Abstract Information


The importance of tissue perfusion in acute and chronic spinal cord injury: New Findings in Animal and Human Models

1Krisa L, 2Jones L, 3Bloom O, 4Papadopoulos M, 5West C, 6Guest J, 7Wecht J
1Thomas Jefferson University, Philadelphia, Pennsylvan, United states; 2Craig H. Neilsen Foundation, Encino, California, United states; 3The Feinstein Institute for Medical Research, Manhasset, NY, USA; 4St. George’s University Hospitals, Wandsworth, , England; 5ICORD (International Collaboration On Repair Discoveries), Vancouver, BC, Canada; 6The Miami project to Cure Paralysis, Miami, FL, USA; 7James J. Peters VA Medical Center and The Mount Sinai School of Medicine, Bronx, NY, USA

This course will discuss translational advancements in tissue perfusion (spinal cord perfusion pressure (SCPP) and blood pressure) in both acute and chronic spinal cord injury (SCI). The first two speakers will present work in human SCI on the impact of SCPP measured with a spinal probe on neurological outcomes in the acute phase of injury. The first speaker is Marios Papadopoulos, a neurosurgeon from St. George’s University in the United Kingdom, will present his findings recording SCPP with a probe at the level of injury. The second speaker is Christopher West, a translational scientist from ICORD, who will speak on the success of using SCPP recorded with a lumbar intrathecal catheter. James Guest, a clinician scientist from the Miami Project to Cure Paralysis, will then present a reverse translation approach, using a mini-pig model to explore optimal monitoring and potential treatments to maintain SCPP. The course will conclude with talk by Jill Wecht, an autonomic physiologist from the James J. Peters VA Medical Center and the Mount Sinai School of Medicine, on the blood pressure dysregulation on individuals with chronic SCI and ways to minimize these deleterious effects. The course will conclude with a question and answer session.


Laura Krisa, Ph.D
Assistant Professor
Thomas Jefferson University

Linda Jones, PT, MS
Program Director
Craig H. Neilsen Foundation

Proposed Faculty

Ona Bloom, PhD
Associate Professor
The Feinstein Institute for Medical Research

Marios Papadopoulos, MD, FRCS(SN)
Professor of Neurosurgery
St. George’s University Hospitals

Christopher West, PhD
Assistant Professor
ICORD (International Collaboration On Repair Discoveries)

James D. Guest, M.D., Ph.D., F.A.C.S., F.R.C.S. (C)
Clinical Professor, Department of Neurological Surgery
The Miami project to Cure Paralysis

Jill M. Wecht, EdD
Associate Professor of Medicine and Rehabilitation Medicine
James J. Peters VA Medical Center and The Mount Sinai School of Medicine

Draft Agenda
0:00-0:05 Opening remarks (Laura Krisa)
0:05-0:20 Marios Papadopoulos, MD
0:20-0:35 Christopher West, PhD, FRCS(SN)
0:35-0:55 James D. Guest, M.D., Ph.D., F.A.C.S., F.R.C.S. (C)
0:55-1:10 Jill M.Wecht, EdD
1:10-1:25 Discussion/Questions (Linda)
1:25-1:30 Closing Remarks (Ona)

Sponsor- This course is sponsored by the Research and Awards Committee


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